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. 2019 Nov 1;10:2540. doi: 10.3389/fimmu.2019.02540

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Copyright © 2019 Costello, Cantillo and Kenter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SHMs occur largely at G/C residues in the IgL gene of MBD4^Δ/Δ subclones. The leader and CDR1, CDR2 and CDR3 motifs in the reference sequence are boxed. Mutations are from the parental (n = 11, black; above the reference sequence) and MBD4^Δ/Δ.11 (n = 8, green), MBD4^Δ/Δ.12 (n = 12, blue), and MBD4^Δ/Δ.14 (n = 12, red) deletion clones, below the reference sequence. The asterisk indicates that the mutated nucleotide sequence was mixed with the parental sequence at that position. AID hotspot motifs (RGYW, WRCY) are highlighted in bold. Nucleotide numbering is indicated at the end of each line.