Table 1.
Potential mechanisms implicated in the underlying neurobiology of PPD in relation to potential mechanisms of action mediating the antidepressant effects of allopregnanolone.
| Mechanisms of Action of Allopregnanolone | Implicated in the Underlying Neurobiology of PPD | Potential Mechanisms Mediating the Antidepressant effects of Allopregnanolone |
|---|---|---|
| GABAergic Dysfunction | + | + |
| HPA Axis Dysfunction | + | + |
| Neurosteroid Deficits | + | + |
| Altered Network Communication | + | ? |
| Neuroprotection | – | – |
| Neuroinflammation | + | ? |
| Genetic Predisposition | + | ? |
| Actions on pregnane X receptors/transcriptional changes and gene regulation | – | ? |
| Actions on membrane progesterone receptors/G-protein-coupled receptors | – | ? |
| Metabotropic Regulation of GABA receptors | – | ? |
+ indicates a strong relationship, - indicates no known interaction, ? Indicates the relationship is currently undetermined.