Fig. 2.

GARD modeling for PeSCC. Individual GARD value was calculated for the 25 penile tumors using commonly prescribed postoperative radiation dose of 50 Gy. The 50th percentile of GARD (18.25, marked with green line) was used to model GARD optimization based on previous validation studies. Green arrow represents lesions with optimal GARD-based therapeutic effects from radiation. Blue arrow represents penile tumors with GARD of 14–18.25, which would benefit from slightly increasing radiation dose prescription to achieve the median GARD of 18.25. Red arrow represents more radioresistant tumors, which would require higher radiation dosing to achieve optimal GARD-based therapeutic effect. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article).