Table 4.

Prognostic factors for OS of patients with metastatic gastric cancer on the univariate and multivariate analysis.

Characteristic	n	MST (m)	Univariate analysis		Multivariate analysis
			HR (95% CI)	P	HR (95% CI)	P
Age	267	14.0	1.003 (0.993–1.014)	0.567
Gender				0.865
Male	181	13.4	Ref
Female	86	15.2	1.024 (0.779–1.346)
Location				0.305
Upper	79	14.1	Ref
Middle	86	13.1	1.260 (0.905–1.755)	0.171
Lower	94	15.4	0.974 (0.702–1.353)	0.877
Diffuse	8	14.2	1.423 (0.681–2.973)	0.348
Differentiation				0.022		0.001
Well/median	61	21.3	Ref		Ref
Poor	206	13.1	1.443 (1.053–1.977)		1.723 (1.231–2.410)
CA19–9 level				<0.001		0.011
Normal	161	15.6	Ref		Ref
Elevated	106	12.2	1.604 (1.219–2.110)		1.459 (1.089–1.956)
CEA level				0.056		0.134
Normal	144	15.4	Ref		Ref
Elevated	123	12.2	1.291 (0.993–1.678)		1.246 (0.935–1.660)
Curative surgery				<0.001		<0.001
No	169	12.2	Ref		Ref
Yes	98	18.3	0.605 (0.461–0.795)		0.588 (0.440–0.786)
Second- and further-line chemotherapy				0.859
No	128	11.3	Ref
Yes	139	15.2	0.976 (0.751–1.270)
Palliative gastrectomy				0.044		0.014
No	232	13.2	Ref		Ref
Yes	35	18.4	0.661 (0.442–0.989)		0.590 (0.387–0.899)
Metastasectomy				0.001		0.007
No	248	13.2	Ref		Ref
Yes	19	35.6	0.423 (0.249–0.720)		0.468 (0.270–0.810)
Intraperitoneal chemotherapy				0.474
No	230	13.2	Ref
Yes	37	17.6	0.872 (0.604–1.264)
Radiotherapy				0.024		0.325
No	215	13.2	Ref		Ref
Yes	52	17.6	0.682 (0.489–0.952)		0.842 (0.597–1.186)