Table 1.
Clinical and pretreatment parameters, follicular fluid and serum concentrations of hormones in 165 patients undergoing ovarian stimulation
| Variables | Successful Pregnancy (N = 72) |
Implantation Failure (N = 93) |
P value |
|---|---|---|---|
| Clinical and treatment parameters | |||
| Age (yrs) | 31 (28,34) | 34 (28,36) | NS |
| BMI (kg/m2) | 22.5 (20.6,25.2) | 20.8 (18.9,22.6) | ≤0.001 |
| Basal FSH | 3.63 (1.95,6.01) | 4.22 (1.79,7.11) | NS |
| AMH (ng/ml) | 3.56 (1.78,3.91) | 3.46 (2.25,4.13) | NS |
| Oocytes (total) | 13.5 (8.8,16.8) | 10 (7,14) | 0.007 |
|
Oocyte (MII) Fertilization rate,% |
10.5 (5.5,15) 65.9% |
8 (6,10) 56.6% |
0.002 ≤0.001 |
| Etiology of infertility(%) | 0.395 | ||
| Female infertility | 75% | 77.4% | |
| Both male and female infertility | 16.7% | 9.7% | |
| Infertility of unknown cause | 8.3% | 12.9% | |
| Cleavage rate,% | 98% | 99.5% | NS |
| Serum (day HCG) hormone levels | |||
| TSH (mIU/l) | 1.86 (1.27,3.08) | 1.95 (1.54,2.95) | NS |
| T4(nmol/l) | 121.9 (104.8,140.8) | 114.1 (98.6,130.6) | 0.026 |
| T3(nmol/l) | 1.98 (1.74,2.22) | 1.98 (1.75,2.13) | NS |
| fT4(pmol/l) | 19.0 (17.7,21.8) | 18.6 (17.0,20.1) | 0.026 |
| fT3(pmol/l) | 4.75 (4.25,4.93) | 4.5 (4.08,4.8) | NS |
| TPO Ab (IU/ml) | 15.1 (9.17,23.22) | 15.5 (8.94,17.32) | NS |
| TG Ab (IU/ml) | 16.6 (13.86,22.2) | 14.4 (13.3,19.9) | NS |
| T4/T3 | 62.5 (55.7,66.2) | 59.4 (53.4,64.9) | 0.029 |
| Follicular fluid hormone levels | |||
| TSH (mIU/l) | 2.12 (1.41,3.57) | 2.41 (2.03.3.23) | NS |
| T4(nmol/l) | 112.3 (93.7124.5) | 102.6 (88.6116.8) | NS |
| T3(nmol/l) | 2.07 (1.88.2.22) | 1.98 (1.75,2.13) | NS |
| fT4(pmol/l) | 19.0 (17.5,21.3) | 18.1 (16.8,19.9) | 0.009 |
| fT3(pmol/l) | 4.67 (4.33,5.0) | 4.19 (4.20,4.88) | NS |
| TPO Ab (IU/ml) | 8.4 (5.0,13.9) | 10.1 (5.0,12.7) | NS |
| TG Ab (IU/ml) | 17.5 (13.98,24.38) | 17.6 (14.9,20.3) | NS |
| T4/T3 | 52.6 (46.4,57.3) | 50.0 (43.7,53.1) | 0.004 |
Note: Values are Mean ± SD, median and interquartile range, or n (%) as indicated
NS nonsignificant,which means P ≥ 0.05
FF follicular fluid, BMI body mass index, AMH anti-Mullerian hormone