Table 3.
SMFA results for Pfs230C1 and Pfs230D1+ as tested in two immunization studies
| Name | Conc [μg/mL] | Mean oocyst | %TRA | (95% CI) | p-value |
|---|---|---|---|---|---|
| Immunization study #1 | |||||
| Control | 750.0 | 10.9 | |||
| C1 (5.0) | 750.0 | 0.2 | 98.2 | (95 to 100) | 0.001 |
| C1 (0.5) | 750.0 | 0.2 | 98.2 | (95 to 100) | 0.001 |
| C1 (0.05) | 750.0 | 1.7 | 84.9 | (65 to 94) | 0.001 |
| D1+ (5.0) | 750.0 | 0.2 | 98.2 | (95 to 100) | 0.001 |
| D1+ (0.5) | 750.0 | 0.2 | 98.2 | (95 to 100) | 0.001 |
| D1+ (0.05) | 750.0 | 0.4 | 96.8 | (92 to 99) | 0.001 |
| Immunization study #2 | |||||
| Control | 750.0 | 39.2 | |||
| C1 (1.0) | 750.0 | 0.5 | 98.9 | (97 to 100) | 0.001 |
| D1+ (1.0) | 750.0 | 0.1 | 99.7 | (99 to 100) | 0.001 |
Purified IgG samples were tested at 750 μg/mL by SMFA with complement. Mean oocyst number, % reduction of oocyst density (%TRA), the 95% confidence interval, and p-value of each test IgG are shown