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. 2019 Nov 8;7:172. doi: 10.1186/s40478-019-0830-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cytokine secretome of PitNETs cell culture supernatants with lower vs higher content of macrophages (a), CD8+ T cells (b) and neutrophils (c). The cutoffs used to define low and high immune cell content were: 6% for macrophages, 1% for CD8+ T cells and 0.5% for neutrophils. Data are shown for the top 12 secreted proteins as mean ± standard error of the mean. *, < 0.05 (Mann Whitney U test)