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. 2019 Nov 8;7:172. doi: 10.1186/s40478-019-0830-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Immune cell infiltrates (a) and immune cell ratios (b) in PitNETs with lower (< 3%) vs higher (≥3%) Ki-67. PitNETs with lower Ki-67, n = 19; PitNETs with higher Ki-67, n = 5. *, < 0.05, **, <0.01 (Mann Whitney U test). c) Percentage of PitNETs with Ki-67 ≥ 3% according to the presence of a “deleterious immune infiltrate phenotype”, i.e. higher content of macrophages, CD4+ T helper lymphocytes, FOXP3+ T regulatory cells and B cells (CD68^hiCD4^hiFOXP3^hiCD20^hi). PitNETs with “deleterious immune infiltrate phenotype”, n = 4; PitNETs without “deleterious immune infiltrate phenotype”, n = 20. ***, <0.001 (Exact Fisher’s test)