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. 2019 Nov 8;19:284. doi: 10.1186/s12935-019-1007-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — TRIM11 interacted with PHLPP1 and promoted its ubiquitination in chordoma cells. a The relative mRNA level of PHLPP1 showed no significant difference between siNC and siTRIM11 transfected cells. b The relative protein level of PHLPP1 was upregulated in siTRIM11 transfected cells, ***p < 0.001 vs siNC. c TRIM11 interacted with PHLPP1 in chordoma cells. d The protein content of PHLPP1 was improved by the proteasome inhibitor MG132, ***p < 0.001 vs siNC, ^##p < 0.01 vs siTRIM11, ^###p < 0.001 vs siTRIM11. e The ubiquitination of PHLPP1 was reduced in siTRIM11 transfected cells