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. 2019 Nov 8;19:284. doi: 10.1186/s12935-019-1007-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Overexpression of PHLPP1 suppressed the function of TRIM11 in chordoma cells. a, b The relative mRNA and protein level of PHLPP1 were significantly upregulated in oePHLPP1 transfected cells. ***p < 0.001 vs oeNC. b Overexpression of PHLPP1 promoted the apoptosis of orTRIM11 transfected cells. *p < 0.05 vs oeNC, ***p < 0.001 vs oeNC; ^###p < 0.001 vs oeTRIM11; ^!!!p < 0.001 vs oePHLPP1. d The phosphorylation of AKT was inhibited in oePHLPP1 transfected cells, ***p < 0.001 vs oeNC; ^###p < 0.001 vs oeTRIM11