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. 2019 Nov 1;10:2578. doi: 10.3389/fimmu.2019.02578

Figure 4.

Figure 4

Effects of prophylactic treatment of OLT1177 EAE mice. (A,B) Average EAE clinical score of mice treated with single-daily i.p. administration of 200 mg/kg (A) or twice-daily administration of 60 mg/kg OLT1177 (B). (C,D) Graph showing the quantification of demyelination in the lumbar spinal cord of mice treated with both OLT1177 doses (C) and representative images of lumbar spinal cord tissue sections stained against LFB from EAE treated with vehicle, single-daily 200 mg/kg and twice-daily 60 mg/kg of OLT1177 (D). *p < 0.05; **p < 0.01; ***p < 0.001 vs. Vehicle. Two-way repeated measures ANOVA with Bonferroni's post-hoc test in (A) (n = 12 in vehicle and n = 10 in OLT1177) and (B) (n = 9 in vehicle and n = 10 in OLT1177); Unpaired t-test in (C) (n = 9 in vehicle and n = 10 in OLT1177). Data shown as mean ± sem.