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. 2019 Nov 1;9:1144. doi: 10.3389/fonc.2019.01144

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Copyright © 2019 Heaster, Landman and Skala.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial clustering patterns of OMI variables in FaDu xenografts. Moran's I based on (A) NAD(P)H τ₂ and (B) FAD τ₂ measurements is plotted across control and treated xenografts. (C–F) Ellipses represent the distribution of cell clusters, with cells falling in the upper right (homogeneously high value clusters) and lower left quadrants (homogeneously low value clusters). Clustering is plotted for each treatment group for (C) NAD(P)H τ₂ and (D) FAD τ₂. Clustering is similarly plotted for responsive and resistant cells for (E) NAD(P)H τ₂ and (F) FAD τ₂.