Table 1.
Comparison of IL-18 polymorphisms among MS patients and healthy subjects
| Loci | Case (n=110) | Control (n=110) | OR (95%CI) | P | |
|---|---|---|---|---|---|
| Rs360719 | Genotype | ||||
| GG | 75 (68) | 80 (73) | Reference | >0.05 | |
| GC | 29 (26) | 27 (24) | 0.469 (0.1131.942) | ||
| CC | 6 (6) | 3 (3) | 0.537 (0.1222.363) | ||
| Allele | |||||
| G | 179 (81) | 187 (85) | >0.05 | ||
| C | 41 (19) | 33 (15) | >0.05 | ||
| Rs1946518 | Genotype | ||||
| AA | 27 (25) | 23 (21) | Reference | 0.037 | |
| AC | 53 (48) | 39 (35) | 1.878 (0.9153.856) | ||
| CC | 30 (27) | 48 (44) | 2.174 (1.1754.025) | ||
| Allele | |||||
| A | 107 (49) | 85 (39) | >0.05 | ||
| C | 113 (51) | 135 (61) | >0.05 | ||
| Rs187238 | Genotype | ||||
| AA | 49 (45) | 66 (60) | Reference | 0.069 | |
| AG | 50 (45) | 37 (34) | 0.472 (0.1711.306) | ||
| GG | 11 (10) | 7 (6) | 0.860 (0.3042.430) | ||
| Allele | |||||
| A | 148 (67) | 169 (77) | >0.05 | ||
| G | 72 (33) | 51 (23) | >0.05 | ||