Table 2.
Gene ontology term enrichment analysis of molecular functions for proteins upregulated in HGSC plasma.
| GO biological process | Enrichment | FDR |
|---|---|---|
| Protein tyrosine kinase activity (GO:0004713) | 13.5 | 8.6e-10 |
| Glycosaminoglycan binding (GO:0005539) | 8.8 | 4.0e-08 |
| Insulin-like growth factor binding (GO:0005520) | 34.9 | 1.3e-07 |
| Cytokine binding (GO:0019955) | 11.4 | 4.7e-07 |
| Heparin binding (GO:0008201) | 9.7 | 5.6e-07 |
| Extracellular matrix binding (GO:0050840) | 18.9 | 8.3e-07 |
| Cell adhesion molecule binding (GO:0050839) | 5.1 | 1.2e-06 |
| Serine-type endopeptidase activity (GO:0004252) | 8.7 | 5.7e-06 |
| Peptidase inhibitor activity (GO:0030414) | 7.2 | 8.5e-05 |
| VEGF-activated receptor activity (GO:0005021) | 69.8 | 1.5e-04 |
| Integrin binding (GO:0005178) | 8.5 | 2.2e-04 |
| TNF-activated receptor activity (GO:0005031) | 54.2 | 2.8e-04 |
| Semaphorin receptor activity (GO:0017154) | 44.3 | 4.7e-04 |
| Death receptor activity (GO:0005035) | 44.3 | 4.8e-04 |
| Scavenger receptor activity (GO:0005044) | 14.1 | 6.4e-04 |
| Laminin binding (GO:0043236) | 21.1 | 6.3e-04 |
| Collagen binding (GO:0005518) | 10.9 | 2.1e-03 |
| Ephrin receptor activity (GO:0005003) | 25.7 | 2.4e-03 |
| Fibronectin binding (GO:0001968) | 17.4 | 8.2e-03 |
| PDGF receptor binding (GO:0005161) | 24.4 | 2.4e-02 |
Enrichment: fold increase over random distribution; FDR, false discovery rate. The table lists the top 20 specific, non-redundant terms yielding a minimum enrichment of 5-fold.