Figure 7.

Pulmonary (left) and systemic (right) impulse response functions (IRFs), i.e., Q _T,PA(t) and Q _T,A(t) derived from the mean values of the fitting parameters ($F/V_{\mathrm{P}}$, γ, $PS/V_{\mathrm{P}}$, $v_{\mathrm{P}}$, $v_{\mathrm{I}}$, and $t_{\text{Lag},\mathrm{T}}$) for each of the dual‐input Tofts‐Kety (TK), extended TK (ETK), two compartment exchange (2CX), adiabatic approximation to the tissue homogeneity (AATH), and distributed parameter (DP) models in malignant pleural mesothelioma (MPM) (upper) and nonsmall cell lung cancer (NSCLC) (lower). The upper IRFs in (a) and (b) were derived from the mean values of the fitting parameters calculated from all voxels (n = 58,367) within the regions of the five MPM cases, whereas the lower IRFs in (c) and (d) were derived from all voxels (n = 165,864) within those of the 10 NSCLC cases, respectively.