Table 1.
Median with 95% confidence interval of tracer kinetic parameters derived from fitting the five pulmonary arterial input tracer kinetic models on all analyzed voxels within MPM (n = 58,367) and NSCLC (n = 165,864).
| Parameter | Lesion | TK | ETK | 2CX | AATH | DP | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BF (mL/min/100g) | MPM | 215.7 (213.5, 217.9) | > | 41.84 (41.42, 42.27) | < | 115.1 (113.9, 116.3) | > | 73.93 (73.10, 74.76) | > | 64.28 (63.58, 65.00) | |
| NSCLC | 85.80 (85.17, 86.43) | > | 10.25 (10.19, 10.32) | < | 27.65 (27.46, 27.84) | > | 16.60 (16.49, 16.71) | > | 15.96 (15.86, 16.07) | ||
|
BV (mL/100g) |
MPM | 32.17 (31.97, 32.38) | > | 12.60 (12.54, 12.67) | < | 29.77 (29.48, 30.06) | > | 23.14 (22.91, 23.37) | < | 27.18 (26.90, 27.46) | |
| NSCLC | 20.48 (20.39, 20.57) | > | 11.06 (11.04, 11.08) | > | 8.846 (8.792, 8.901) | > | 6.373 (6.333, 6.413) | < | 7.129 (7.085, 7.174) | ||
|
MTT (min) |
MPM | 0.312 (0.309, 0.314) | < | 1.159 (1.148, 1.171) | < | 1.269 (1.257, 1.281) | < | 1.617 (1.603, 1.631) | < | 2.149 (2.133, 2.166) | |
| NSCLC | 0.301 (0.299, 0.303) | < | 4.836 (4.789, 4.862) | > | 2.665 (2.641, 2.688) | > | 1.741 (1.729, 1.754) | < | 2.459 (2.444, 2.474) | ||
| PS (mL/min/100g) | MPM | 57.06 (56.28, 57.87) | > | 8.276 (8.232, 8.321) | < | 13.09 (12.88, 13.31) | < | 14.98 (14.77, 15.19) | > | 9.886 (9.770, 10.00) | |
| NSCLC | 17.71 (17.58, 17.85) | > | 7.482 (7.466, 7.498) | > | 2.404 (2.382, 2.425) | < | 4.385 (4.352, 4.418) | > | 2.443 (2.428, 2.458) | ||
|
|
MPM | 0.454 (0.449, 0.458) | > | 0.150 (0.150, 0.150) | < | 0.620 (0.617, 0.623) | > | 0.569 (0.567, 0.571) | < | 0.635 (0.633, 0.638) | |
| NSCLC | 0.118 (0.117, 0.118) | < | 0.150 (0.150, 0.150) | < | 0.467 (0.461, 0.473) | > |
0.151 (0.149, 0.152) |
< | 0.227 (0.225, 0.230) | ||
|
K Trans (mL/min/mL) |
MPM | 0.466 (0.460, 0.473) | > | 0.073 (0.072, 0.073) | < | 0.110 (0.109, 0.112) | < | 0.123 (0.121, 0.125) | > | 0.085 (0.084, 0.086) | |
| NSCLC | 0.126 (0.125, 0.127) | > | 0.035 (0.035, 0.035) | > | 0.021 (0.021, 0.021) | < | 0.034 (0.034, 0.034) | > | 0.021 (0.021, 0.021) | ||
|
|
MPM | 0.010 (0.009, 0.011) | > | 0.000 (0.000, 0.000) | < | 0.320 (0.316, 0.325) | < | 0.339 (0.336, 0.342) | > | 0.200 (0.198, 0.202) | |
| NSCLC | 0.019 (0.018, 0.019) | > | 0.000 (0.000, 0.000) | < | 0.354 (0.352, 0.357) | > | 0.307 (0.306, 0.309) | > | 0.216 (0.215, 0.217) |
“>” or “<” indicates significant difference (P < 0.01) between adjoining models in the Wilcoxon signed rank test.