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. 2019 Oct 29;25:8095–8104. doi: 10.12659/MSM.916075

Figure 4.

Figure 4

Overexpression of miR-144-3p increased chemosensitivity to DDP in H460/DDP and A549/DDP cells. (A) miR-144-3p mimic or NC mimic were transfected into H460/DDP and A549/DDP cells. The quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay was performed to measure the level of miR-144-3p. (B–E) The survival rate and proliferation were elevated in H460/DDP and A549/DDP cells using the MTT assay. (F) Cell apoptosis was examined in H460/DDP and A549/DDP cells using flow cytometry. (G–I) The protein levels of MDR1 and MRP1 in A549/DDP and H460/DDP cells were measured by Western blot. (J, K) Cell migration and invasion abilities were increased in cells transfected with miR-144-3p mimic or negative control (NC) mimic. * p<0.05.