Figure 1c.

Bone Blood flow in the Proximal Tibia measured by ¹⁸F-fluoride by PET/CT. Mice were treated with oral dexamethasone alone or with LLP2A-Ale (500ug/kg at day1,14,28) or PTH (1–34) 5 days/week for 45 days. At day −1, and day 45 mice from each treatment group (n=6) had PET/CT scanning with the radiotracer ¹⁸F-fluoride to measure blood flow in vivo. Dynamic PET data were analyzed via a two-compartment, four-parameter model, and values of the rate constant K₁ were compared between groups (Mean ± SD). At baseline, there were no differences in the K₁ between the treatment groups. At day 45, compared to the placebo group, the GC group had a significant reduction in blood flow, and GC + PTH group had a significant increase compared to the placebo group.