Fig.2.

Physiological roles of the CR of APs in microorganisms. a) Bacterial curli protein promotes the conversion of PAP_248–286 into the amyloid SEVI. Electron microscopic images of SEVI fibers formed in the absence of curli (left) and in the presence of 5 mol% CsgA (middle) and CsgB (right) fibers. Fibers were grown at a concentration of 440μM PAP248–286 at 37°C under 1400 rpm orbital shaking for 7 days. Bars = 500 nm. Quantification of the fibers are shown. b) Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae. Modified from Hartman et al. [30] (a) and Keefer et al. [31] (b) with permission.