Table 1.

Comparison of the APM with other hypotheses; the EVH and the ACH. The APM was compared with two other hypotheses, the ACH and the EVH, in terms of ‘biological significance’, ‘life-stage’, ‘inheritance’, ‘role of the CS of APs’, ‘role of Aβ’, and ‘experimental approach’

	ACH	EVH	APM
Role of the CS of APs	Pathological	Physiological	Physiological
Life-stage	Aging	Development/Reproduction	Development/Reproduction, Aging
Inheritance	Not addressed	Inheritance of acquired characteristic	Not addressed
Experimental approach	Reccombinant proteins, Cells, and Animals	To be addressed	Cells and Animals
Role of Aβ	Dominant	Similar to other APs	Exclusive