Table 2.
Summary statistics for change in the values of the outcome measures from baseline to year-5 of follow-up. NC, not collected
| Outcome | BL* | Change* from BL to Year 1** | Change* from BL to Year 2** | Change* from BL to Year 3** | Change* from BL to Year 4** | Change* from BL to Year 5** |
| MDS-UPDRS Total Score Off | 32.2 (13.1; 7–70; 1) | 7.5 (11.6; –31–60; 79) | 10.4 (12.9; –30–60; 131) | 14.3 (15.6; –35–78; 158) | 19.1(16.5; –20–84; 164) | 20.9 (17.7; –11–111; 250) |
| MDS-UPDRS Total Score On | 32.2 (13.1; 7–70; 1) | 5.4 (12.7; –38–60; 32) | 7.0 (13.4; –33–60; 59) | 9.8 (16.6; 40–79; 71) | 11.9 (18.0;–35–103; 92) | 15.2 (19.4; 24–111; 208) |
| MDS-UPDRS III Score Off | 20.9 (8.9; 4–51; 0) | 4.5 (8.2; –22–34; 79) | 6.3 (9.3; –28–45; 130) | 8.8 (10.9; –28–54; 158) | 11.6 (11.3;–20–54; 164) | 12.3 (11.8; 3–64; 250) |
| MDS-UPDRS III Score On | 20.6 (8.9; 4–51; 0) | 2.5 (9.1; –25–34; 31) | 2.6 (10.1; –31–45; 58) | 3.7 (11.8; –31–39; 70) | 4.1 (12.6; –27–48; 91) | 5.6 (12.3; –27–58; 208) |
| Putamen SBR | 0.82 (0.3; 0.2–2.2; 3) | –13.4 (21.8; –83.1–141.2; 45) | –19.2 (21.5; –86.7–167.7; 67) | NC | –30.9 (21.0; –83.3–123.2; 132) | NC |
| Striatum SBR | 1.4 (0.4; 0.3–2.6; 3) | –11.2 (15.1;–59.6–124.8; 45) | –17.1 (16.6; –87.5–146.2; 67) | NC | –27.7 (16.8; –83.0–104.3; 132) | NC |
*% Change from baseline shown for mean putamen SBR and mean striatum SBR. **Values shown are mean (SD; range (min–max); number missing) for all continuous variables.