Table 3.
Patient clinical characteristics and comorbidities across cohorts*
| Description | Overall | MCI[+] | MCI[–] | p† | MILD[+] | MILD[–] | p† |
| N = 1198 | N = 300 | N = 281 | N = 317 | N = 300 | |||
| Time since AD-related diagnosis, mean (SD) y | 1.5 (2.2) | 1.0 (1.3) | 1.5 (2.0) | 0.003 | 1.5 (2.3) | 2.1 (2.6) | <0.001 |
| Time since first symptoms, mean (SD) y | 3.2 (2.9) | 2.7 (2.4) | 3.5 (3.1) | 0.002 | 3.2 (3.1) | 3.5 (2.8) | 0.208 |
| First degree relative with AD, n (%) | 324 (27.1) | 82 (27.6) | 97 (34.5) | 0.131 | 68 (21.5) | 77 (25.7) | 0.057 |
| Interactions with police, fire, or ambulance services due to cognitive symptoms over last 3 months, n (%) | 18 (1.5) | 3 (1.0) | 1 (0.4) | 0.402 | 7 (2.2) | 7 (2.3) | 0.864 |
| Accidental falls over last 3 months, n (%) | 120 (10.1) | 24 (8.0) | 18 (6.4) | 0.329 | 46 (14.6) | 32 (10.7) | 0.357 |
| Number of falls, mean (SD) | 2.1 (1.8) | 1.8 (1.1) | 1.5 (0.7) | 0.544 | 2.2 (1.9) | 2.6 (2.3) | 0.395 |
| Any comorbidity, n (%)‡ | 1051 (87.7) | 263 (87.7) | 245 (87.2) | 0.984 | 272 (85.8) | 271 (90.3) | 0.073 |
| Number of comorbidities, mean (SD) | 2.4 (1.8) | 2.3 (1.5) | 2.2 (1.6) | 0.538 | 2.3 (1.7) | 2.8 (2.2) | <0.001 |
| Hypertension, n (%) | 723 (68.8) | 191 (72.6) | 152 (62.0) | 0.011 | 191 (70.2) | 189 (69.7) | 0.903 |
| Hypercholesterolemia, n (%) | 513 (48.8) | 132 (50.2) | 114 (46.5) | 0.410 | 128 (47.1) | 139 (51.3) | 0.324 |
| Depression, n (%) | 467 (44.4) | 94 (35.7) | 112 (45.7) | 0.022 | 110 (40.4) | 151 (55.7) | <0.001 |
| Sleep disorders, n (%) | 290 (27.6) | 57 (21.7) | 68 (27.8) | 0.112 | 72 (26.5) | 93 (34.3) | 0.047 |
| Diabetes mellitus, n (%) | 301 (28.6) | 76 (28.9) | 61 (24.9) | 0.310 | 72 (26.5) | 92 (33.9) | 0.058 |
| Obstructive pulmonary disease, n (%) | 78 (7.4) | 11 (4.2) | 17 (6.9) | 0.174 | 18 (6.6) | 32 (11.8) | 0.036 |
| Coronary artery disease, n (%) | 111 (10.6) | 28 (10.6) | 15 (6.1) | 0.067 | 34 (12.5) | 34 (12.5) | 0.987 |
AD, Alzheimer’s disease; MCI, mild cognitive impairment; MILD, mild dementia; SD, standard deviation; +, amyloid positive; –, amyloid negative. *Percentages are based on the number of respondents. †p-values were computed for continuous versus categorical data from t-test or chi-squared test, respectively. ‡12 comorbidities interrelated to AD were evaluated.