Table 4.
Baseline health-related outcome measures across cohorts, mean (SD)*
| Description | Range | Overall | MCI[+] | MCI[–] | p§ | MILD[+] | MILD[–] | p§ |
| N = 1198 | N = 300 | N = 281 | N = 317 | N = 300 | ||||
| MMSE | 0–30↓† | 26.0 (2.8) | 27.4 (1.8) | 27.6 (1.9) | 0.235 | 24.4 (2.8) | 24.8 (2.8) | 0.052 |
| ADAS-Cog-13 | 0–85↑‡ | 22.0 (10.1) | 16.6 (7.5) | 17.2 (8.5) | 0.428 | 27.3 (10.0) | 26.6 (9.0) | 0.269 |
| FAQ | 0–30↑‡ | 8.7 (7.6) | 2.3 (1.7) | 2.3 (1.9) | 0.971 | 15.6 (6.4) | 13.8 (5.3) | <0.001 |
| CFI-patient, total | 0–15↑‡ | 5.8 (3.8) | 4.5 (3.2) | 4.5 (3.1) | 0.972 | 7.6 (3.9) | 8.3 (3.8) | 0.200 |
| CFI-study partner, total | 20–100↑‡ | 54.6 (15.2) | 47.0 (14.0) | 45.8 (13.1) | 0.241 | 63.7 (13.4) | 61.0 (11.0) | 0.011 |
| Change subscale | 20–100↑‡ | 69.1 (9.3) | 65.1 (8.9) | 66.6 (7.3) | 0.043 | 73.2 (10.3) | 70.8 (8.2) | <0.001 |
| Concern subscale | 20–100↑‡ | 55.6 (20.9) | 48.8 (22.1) | 46.1 (19.8) | 0.315 | 60.7 (19.6) | 64.9 (15.4) | 0.092 |
| Spearman correlation coefficient between patient and partner | 0.540 | 0.508 | 0.366 | 0.413 | 0.319 | |||
| <0.001 | <0.001 | <0.001 | <0.001 | 0.004 | ||||
| NPI, total | 0–144↓† | 6.9 (10.4) | 4.9 (9.0) | 4.3 (6.8) | 0.454 | 8.9 (11.7) | 9.2 (12.1) | 0.721 |
| BASQID, total | 0–100↓† | 54.6 (20.7) | 64.7 (18.5) | 60.8 (19.9) | 0.014 | 49.8 (19.2) | 43.6 (18.2) | <0.001 |
| BASQID, life satisfaction | 0–100↓† | 50.8 (20.4) | 59.7 (19.3) | 56.3 (20.3) | 0.032 | 46.7 (18.7) | 40.8 (17.8) | <0.001 |
| BASQID, feelings of positive quality of life | 0–100↓† | 58.7 (23.1) | 70.3 (19.7) | 65.9 (21.4) | 0.012 | 53.0 (22.1) | 46.4 (21.0) | <0.001 |
| Zarit Burden Inventory | 0–88↑‡ | 17.5 (14.9) | 12.4 (13.4) | 12.2 (12.8) | 0.857 | 20.8 (14.9) | 24.1 (14.5) | 0.004 |
| Desire to Institutionalize | 0–6↑‡ | 0.3 (1.0) | 0.2 (0.7) | 0.2 (0.8) | 0.749 | 0.5 (1.3) | 0.4 (1.1) | 0.028 |
| Individual items, yes n (%) | ||||||||
| Considering | 61 (5.1) | 6 (2.0) | 7 (2.5) | 0.689 | 28 (8.9) | 20 (6.7) | 0.316 | |
| Felt better off | 62 (5.2) | 10 (3.3) | 9 (3.2) | 0.930 | 24 (7.6) | 19 (6.4) | 0.547 | |
| Discussed with family | 106 (8.9) | 15 (5.0) | 16 (5.7) | 0.709 | 48 (15.2) | 27 (9.0) | 0.020 | |
| Discussed with patient | 90 (7.5) | 18 (6.0) | 15 (5.4) | 0.731 | 39 (12.3) | 18 (6.0) | 0.007 | |
| Taken step towards placement | 24 (2.0) | 1 (0.3) | 4 (1.4) | 0.155 | 11 (3.5) | 8 (2.7) | 0.564 | |
| Likely to move patient | 36 (3.0) | 2 (0.7) | 5 (1.8) | 0.219 | 16 (5.1) | 13 (4.3) | 0.676 |
ADAS-Cog13, Alzheimer’s Disease Assessment Scale – Cognitive subscale; BASQID, Bath Assessment of Subjective Quality of Life in Dementia; CFI, Cognitive Function Instrument; FAQ = Functional Activities Questionnaire; MCI, mild cognitive impairment; MILD, mild dementia; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory; SD, standard deviation; +, amyloid positive; –, amyloid negative. *All percentages are based on the number of respondents. †Lower scores equal poorer status ↓. ‡Higher scores equal poorer status ↑. §p-values were computed for continuous versus categorical data from t-test or chi-squared test, respectively.