Figure 3.

Rehabilitation efficacy of simvastatin and HFD toward radiation‐induced gastrointestinal toxicity relates to sexual dimorphism. Male and Female mice were exposed to 12 Gy total abdominal irradiation, the colon and small intestine tissues were obtained at day 21, n = 24 per group. A,B) Photographs of dissected colon from male A) and female B) mice in the four groups. C,D) The morphology of the small intestine form male C) and female D) mice was shown by H&E and PAS staining. The black arrows point to the goblet cells. E,F) The levels of LCN2 in fecal pellets from male E) and female F) mice were examined by ELISA. Significant differences are indicated: *P < 0.05, **P < 0.01, ***P < 0.005 by Student's t‐test between each two cohort. G,H) The expression levels of Glut1 are examined in small intestine tissues from male G) and female H) mice by quantitative PCR. Significant differences are indicated: *P < 0.05 by Student's t‐test between each two cohort. I,J) The levels of MDA were assessed in small intestine tissue from male I) and female J) mice. Significant differences are indicated: *P < 0.05, **P < 0.01, ***P < 0.005 by Student's t‐test between each two cohort. K,L) The levels of FITC‐dextran in PB from male K) and female L) mice were assessed. Significant differences are indicated: *P < 0.05 by Student's t‐test between each two cohort.