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. 2019 Aug 29;6(21):1901048. doi: 10.1002/advs.201901048

Figure 5.

Figure 5

Simvastatin and HFD administration shape intestinal bacterial structure at day 14 after TAI in a sexual‐dependent fashion. A,B) The observed species number A) and Chao1 diversity index B) of enteric bacteria in male mice was measured by 16S rRNA high‐throughput sequencing at 14 d after TAI exposure. Significant differences are indicated: Wilcoxon rank sum test. n = 5 (control group) or 6 (irradiated groups). C,D) The observed species number C) and Chao1 diversity index D) of enteric bacteria in female mice was measured by 16S rRNA high‐throughput sequencing at 14 d after TAI exposure. Significant differences are indicated: Wilcoxon rank sum test. n = 5 (control group) or 6 (irradiated groups). E,F) PCoA were performed to assess the alteration of gut bacteria taxonomic profile from male E) and female F) mice after TAI at day 14. n = 5 (control group) or 6 (irradiated groups). G,H) The β diversity of intestinal bacteria was compared by weighted unifrac analysis. Significant differences are indicated: Wilcoxon rank sum test. n = 5 (control group) or 6 (irradiated groups). I–L) The abundances of most varied strain bacteria in male I,J) and female K,L) mice was examined using 16S high‐throughput sequencing after TAI at day 14. Significant differences are indicated: Wilcoxon rank sum test. n = 5 (control group) or 6 (irradiated groups).