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. 2019 Aug 29;6(21):1901048. doi: 10.1002/advs.201901048

Figure 6.

Figure 6

The optimal therapeutic options reprogram radiation‐shaped gene expression profile of mice small intestines. In this experiment, male mice were divided into three groups. One group was exposed to 12 Gy TAI, one group was treated with simvastatin following 12 Gy TAI exposure, another group was control. Female mice were also divided into three groups. One group was exposed to 12 Gy TAI, one group was fed with HFD following 12 Gy TAI exposure, another group was control. Small intestine tissues were obtained at day 21 after irradiation. A–D) Cluster analysis of differentially expressed miRNA of small intestine tissues from male A,B) and female C,D) mice. A: control group versus TAI group, B: simvastatin group versus TAI group, C: control group versus TAI group, D: HFD group versus TAI group. E–L) Bioinformatics analysis of different proteins clustered into pathways of small intestine tissues from male and female mice through KEGG. M,N) Kaplan–Meier analysis of overall survival rate of prostatic cancer and ovarian cancer patients. P < 0.05 by log‐rank test between the patients with high and low expression of HMGCR.