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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Drug Discov Today. 2018 Aug 16;24(2):462–491. doi: 10.1016/j.drudis.2018.08.009

FIGURE 9.

FIGURE 9

H&E Histological sections of organs from glioma-bearing rats after being treated with saline, 6 mg kg−1 free DOX four times, an equivalent dose of DOX-Ps 80-SPIONs and an equivalent dose of DOX-Ps 80-SPIONs with magnetic field formulations for 28 days. The result revealed no cardiac toxicity for the encapsulated DOX when compared to free DOX. RES organs such as liver, spleen, lung, and kidney, showed minor changes for the formulation when compared to free DOX. The images are adapted with permission [117].