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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 May 16;39(7):1475–1482. doi: 10.1161/ATVBAHA.118.312236

Table 2.

Hazard ratios relating metabolite risk score with incident coronary heart disease.

Contrast HR 95% CI P-value
Continuous MRS (per SD change) 1.37 1.27- 1.47 <2×10−16
 MRS Quartiles Q2 vs. Q1 1.08 0.82- 1.43 0.57
Q3 vs. Q1 1.36 1.04- 1.77 0.02
Q4 vs. Q1 2.21 1.72- 2.84 6.51×10−10
Trend 4.63×10−13

Abbreviations: HR, hazard ratio; CI, confidence interval; MRS, metabolite risk score; SD, standard deviation. Each model adjusted for age, sex, race, study center, phase, smoking status, systolic blood pressure, anti-hypertensive medication use, diabetes status, total cholesterol, and high-density lipoprotein cholesterol levels.