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. 2019 Jan 30;68(11):2044–2056. doi: 10.1136/gutjnl-2018-316091

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Progression of chronic HBV infection induced hepatitis and liver cirrhosis in dual humanised human bone marrow mesenchymal stem cell-Fah^-/- Rag2^-/- IL-2Rγc^-/- SCID (hBMSC-FRGS) mice. A novel dual-humanised mouse model with efficient chimerism of human liver cells and human immune cell lineages was developed using a single transplantation of hBMSCs, which were sensitive to chronic HBV infection and generated sustained human immune and inflammatory responses that led to liver cirrhosis. FHF, fulminant hepatic failure.