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. 2019 Nov 4;14:8627–8645. doi: 10.2147/IJN.S220754

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© 2019 Diao et al.

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Scheme 1 — Structure and treatment strategy of TAT-CLs-DHA/siRNA. The mechanism of TAT-CLs-DHA/siRNA is to inhibit the TLR4 signaling pathway to therapy LN. The therapy was based on a synergistic effect involving the HMGB1 siRNA and DHA which the siRNA binds to HMGB1 mRNA and the DHA act on the TLR4 signal pathway of immune cell.