Figure 2.

Representative metabolites within significantly enriched metabolic pathways. All metabolites have been matched by an M+H adduct in positive electrospray ionization mode. Abbreviations: NWO, normal weight obesity; HPODE, hydroperoxy-octadecadienoic acid, an intermediate of linoleic acid metabolism and precursor for the oxidized metabolite octadecadienoic acid; HODE, hydroxyoctadecadienoic acid, a derivative of linoleic acid; EpOME, Epoxyoctadecenoic acid, a peroxidation product of linoleic acid.

*Indicates that findings were confirmed in post-hoc analyses with further adjustment for VO2 maximum, and in a subset of the cohort (n=86) with subjects categorized as having normal weight obesity or overweight-obesity matched by age, race/ethnicity, and sex.

† Following further adjustment with VO2 maximum, metabolite was similar between all three groups.