Table 2.

Changes in Functional Connectivity Strength from Pre-surgery to 12-months Post-surgery (Whole-Brain Seed Voxel Resting-State Functional Connectivity Analysis)

Nodes showing decreased magnitude and changes in directionality (positively correlated to anticorrelated) of FC from pre- to post-surgery
Network/Seed 2,3	Cluster	L/R	MNI (x, y, z)	Cluster size	ß	T (p-FDR)1
Default Mode Network Seeds
R Lateral Parietal Cortex	Cerebellum	R	+12, −58, −56	197	−0.27	−11.20 (<0.001)
	Middle Temporal Gyrus, temporoocippital part	L	−64, −48, +4	107	−0.26	−7.41 (0.005)
	Supramarginal Gyrus, anterior division	L	−68, −36, +28	76	−0.26	−6.03 (0.022)
	Postcentral Gyrus	R	+48, −26, +64	67	−0.29	−6.33 (0.029)
Posterior Cingulate Cortex	Lateral Occipital Cortex, superior division	L	−32, −72, +36	100	−0.26	−6.69 (0.011)
Salience Network Seeds
R Supramarginal Gyrus	Lateral Occipital Cortex, superior division	L	−24, −70, +52	119	−0.25	−7.15 (0.002)
	Lateral Occipital Cortex, superior division	R	+14, −66, +66	90	−0.27	−6.81 (0.006)
	Middle Frontal Gyrus	R	+26, +34, +54	68	−0.23	−6.44 (0.017)
	Cerebellum	L	−40, −50, −30	50	−0.23	−9.40 (0.043)
Anterior Cingulate Cortex	Superior Parietal Lobule	L	−44, −52, +58	73	−0.27	−6.55 (0.021)
R Rostrolateral Prefrontal Cortex	Paracingulate Gyrus	R	+12, +44, −4	91	−0.28	−7.15 (0.010)
Frontoparietal Network Seeds
L Posterior Parietal Cortex	Lateral Occipital Cortex, superior division	R	+36, −72, +48	274	−0.29	−7.63 (<0.001)
	Cingulate Gyrus, anterior division		+10, +30, −10	78	−0.34	−6.74 (0.042)
	Angular Gyrus	R	+58, −54, +34	72	−0.28	−6.07 (0.042)
	Cerebellum	L	−8, −54, −52	66	−0.28	−6.03 (0.042)
	Frontal Pole	R	+30, +48, +6	63	−0.28	−7.42 (0.042)
	Frontal Medial Cortex		−2, +48, −20	62	−0.21	−8.40 (0.042)
	Supramarginal Gyrus, anterior division	R	+68, −22, +30	57	−0.30	−5.68 (0.050)
R Posterior Parietal Cortex	Lateral Occipital Cortex, superior division	R	+32, −64, +62	158	−.030	−9.00 (<0.001)
	Supramarginal Gyrus, posterior division	L	−48, −50, +56	65	−0.29	−7.59 (0.041)
	Frontal Pole	R	+12, +56, +6	64	−0.30	−7.18 (0.041)
	Lateral Occipital Cortex, superior division	L	−34, −58, +58	58	−0.27	−7.80 (0.041)
	Lateral Occipital Cortex, superior division	L	−52, −58, +44	58	−0.25	−7.49 (0.041)
L Lateral Prefrontal Cortex	Occipital Pole	R	+14, −94, −18	96	−0.24	−7.15 (0.009)
Nodes showing changes in directionality (anticorrelated to positively correlated) of FC from pre- to post-surgery
Network/Seed	Cluster	L/R	MNI (x, y, z)	Cluster size	ß	T (p-FDR)1
Salience Network Seeds
R Rostrolateral Prefrontal Cortex	Pallidum	L	−16, −10, +2	117	0.29	9.24 (0.007)
Frontoparietal Network Seeds
L Posterior Parietal Cortex	Occipital Pole	L	−10, −94, −22	91	0.26	7.80 (0.010)
	Frontal Pole	L	−32, +62, +16	62	0.26	6.93 (0.031)

¹Height threshold p<0.001, p-uncorrected and cluster threshold p<0.05, cluster-size p-FDR corrected.

²These set of nodes were tested bilaterally and significant results are presented in the current table.

³Complete list with tested nodes is presented in Table S1, Supporting Information.