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. 2019 Jun 21;68(11):2019–2031. doi: 10.1136/gutjnl-2019-318912

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Differences in tumour cell metabolism and cytokine/chemokine expression among the three HCC subtypes. (A) Metabolomic analysis revealed featured alterations of TCA cycle, glycolysis, urea cycle, and nucleotide biosynthesis pathway in different HCC subtypes. (B) Hierarchical clustering of differentially expressed genes in the three HCC subtypes. (C) KEGG pathway enrichment of RNA- seq data showed significant changes in metabolism among the three HCC subtypes. Arrows indicate metabolism-related pathways. (D) Expression of important chemokines, cytokines, and other secretory biomaterials among the three HCC subtypes is shown. Data derived from RNA-seq. *P<0.05; **P< 0.01; ***P< 0.001.