Figure 2.

(a) A schematic view of the interactions of benzoylecgonine and h2E2 Fab generated by LigPlot+ (Laskowski & Swindells, 2011 ▸). (b) A view of the complex structure showing the binding-site interactions between benzoylecgonine (C atoms in cyan) and the variable-region residues of the h2E2 Fab (C atoms in green). The ligand and the binding residues from the Fab are shown as stick drawings, whereas the V_L and V_H domains are shown as a C^α carton in green. (c) A view of the electron density observed in a 2mF _o − DF _c OMIT map is shown for benzoylecgonine and the surrounding residues contoured at 1σ. (d) Chemical representation of cocaine and its analogs benzoylecgonine and cocaethylene.