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. 2018 Jan 13;68(1):177–178. doi: 10.1136/gutjnl-2017-315841

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15Phe genotype influences Blautia faecal abundance. (Left) Genotype-stratified correlation between starch intake and Blautia faecal microbiota abundance (each circle represents an individual). A trend was identified when comparing the two sucrase-isomaltase (SI) 15Phe genotype groups for their starch-bacteria correlations (age/sex/body mass index (BMI)/total energy (TE)-adjusted generalised linear model (GLM) with negative-binomial distribution, and interaction term for genotype and starch intake), in that increasing starch intake corresponds to higher Blautia abundance in 15Phe carriers compared with non-carriers (uncorrected P=0.054). (Right) Blautia faecal microbiota abundance in the two SI genotype groups stratified according to IBS status was significantly increased in IBS cases carrying the 15Phe variant (P=0.00041, beta=0.80), while there was no significant association in non-carriers (P=0.31, beta=0.33). Association analysis was performed using GLM age/sex/BMI/TE adjusted (glm.nb in stats/R). Plots were made using ggplot in ggplot2/R with stat_smooth and method=lm (left panel), and square root transformation of Blautia relative abundance (right panel).