Table 1. Regulation of M. abscessus mycolate synthesis operon in Ac and Mϕ.
| Mmaa gene | Encoded protein | Mabsb gene | FC Ac 4 hpi | FC Ac 16 hpi |
FC Mϕ 16 hpi |
|---|---|---|---|---|---|
| MYCMA_RS13950 | Acyl carrier protein | MAB_2027 | -3.28 (3.15E-17) |
-2.91 (3.08E-07) |
NCc |
| MYCMA_RS13945 | 3-oxoacyl-ACP synthase (Kas B) | MAB_2028 | -2.68 (3.42E-10) |
-2.24 (8.40E-04) |
NC |
| MYCMA_RS13940 | Beta-ketoacyl synthase | MAB_2029 | -2.95 (8.03E-11) |
-4.48 (8.40E-04) |
NC |
| MYCMA_RS13935 | 3-oxoacyl-ACP synthase (Kas A) | MAB_2030 | -3.80 (8.03E-11) |
-3.15 (3.94E-03) |
-1.06 (5.38E-03) |
| MYCMA_RS13930 | Beta-ketoacyl synthase | MAB_2031 | -2.92 (1.02E-08) | NC | -1.85 (3.66E-03) |
| MYCMA_RS13925 | 3-oxoacyl-ACP reductase | MAB_2032 | -2.16 (1.92E-05) | NC | NC |
| MYCMA_RS13920 | Thioesterase | MAB_2033 | -2.09 (3.06E-04) |
NC | NC |
| MYCMA_RS13915 | Malonyl CoA-ACP transacylase | MAB_2034 | -2.09 (3.06E-04) |
NC | NC |
| MYCMA_RS13910 | Acyltransferase | MAB_2035 | NC | NC | NC |
| MYCMA_RS13905 | Membrane protein (MmpS) | MAB_2036 | -1.16 (1.36E-02) |
NC | -1.06 (6.55E-03) |
| MYCMA_RS13900 | Hypothetical protein (MmpL) | MAB_2037 | -0.68 (8.24E-03) |
-0.86 (8.24E-03) |
-0.72 (6.97E-07) |
| MYCMA_RS13895 | Transporter | MAB_2038 | NC | NC | NC |
| MYCMA_RS13890 | Lipase (LipH) | MAB_2039 | NC | 0.86 (1.61E-02) |
0.64 (7.73E-03) |
aMma gene: Mycobacterium massiliense gene (accession number NC_018150.2).
bMabs gene: Mycobacterium abscessus gene (accession number NC_010397.1).
cNC: no change in gene expression
P-values are indicted in brackets.