Fig 3. Association between miRNAs and asthma phenotypes.

Association between miR-21-5p and miR-155-5p with symptomatic asthma and positive bronchodilation without symptoms in both sets development and validation set. Inverse association between miR-155-5p and negative bronchodilation with asthma symptoms. Asthma: defined based on positive bronchodilation or self-reported medical diagnosis with reported symptoms in the previous year; Symptomatic asthma: defined by “asthma” in a child with current symptoms; BD+S-: Positive bronchodilation without asthma symptoms defined by “asthma” in a child with a current positive bronchodilation test and without symptoms; BD-S+: Negative bronchodilation with asthma symptoms defined by “asthma” in a child with a current negative bronchodilation test and with symptoms.