Table 1. Comparison of in vitro 3D BMPS model data with in vivo data for OP toxicity.
| Chemical | AChE activity (IC50, M) (95% CI) |
Toxicity (LC50, M) (95% CI) |
In vivo (LD50,mg/kg) (toxicity source) |
|---|---|---|---|
| Chlorpyrifos (CPF) | 2.735E-1 (7.634E-4 ~ noncomplete CI) |
3.949E-4 (1.118E-4 ~ 8.145E-4) |
96 (Oral-human) |
| Malathion (MT) | 1.805E-3 (7.670E-4 ~ 5.600E-3) |
1.171E-3 (9.216E-4 ~ 1.494E-3) |
369 (Oral-rat) |
| Parathion (PT) | 4.338E-6 (1.113E-6 ~ 1.036E-5) |
8.924E-3 (5.727E-3 ~ 1.409E-2) |
25 (Oral-human) |
| Diisopropyl fluorphosphate (DFP) |
1.863E-3 (9.180E-4 ~ 4.635E-3) |
1.781E-5 (5.007E-8 ~ 2.251) |
6 (Oral-rat) |
| Dimethyl methylphosphonate (DMMP) |
4.159E-1 (1.253E-1 ~ noncomplete CI) |
1.217E-1 (1.651E-2 ~ 1.763) |
8210 (Oral-rat) |
| Diethyl methylphosphonate (DEMP) | 1.971E-1 (9.826E-2 ~ 4.933E-1) |
2.307E-1 (2.415E-1 ~ noncomplete CI) |
800 (Intraperitoneal-mouse) |
| Diethyl cyanophosphonate (DECP) | 1.075E-05 (2.475E-6 ~ 5.813E-5) |
8.948E-6 (5.919E-9 ~ 3.906E-3) |
1.4 (Intraperitoneal-mouse) |
| Diethyl chlorophosphate (DCP) | 8.688E-06 (1.603E-6 ~4.302E-5) |
4.094E-3 (6.202E-4 ~ 7.146E-2) |
11 (Oral-rat) |