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. 2019 Nov 8;14(11):e0224727. doi: 10.1371/journal.pone.0224727

Table 1. Correlation between the expression of THBS4 in tumor stromal cells and clinicopathologic features in 584 patients with gastric carcinoma.

THBS4
High
(n = 223, 38.2%)
Low
(n = 361, 61.8%)
p value
Age (year-old)
    < 65 105 (47.1%) 151 (41.8%)
    ≥ 65 118 (52.9%) 210 (58.2%) 0.247
Gender
    Female 97 (43.5%) 162 (44.9%)
    Male 126 (56.5%) 199 (55.1%) 0.810
αSMA expression
    High 139 (62.3%) 136 (37.7%)
    Low 84 (37.7%) 225 (62.3%) <0.001
Macroscopic type
    type 4 52 (23.3%) 9 (2.5%)
    Other types 171 (76.7%) 352 (97.5%) <0.001
Tumor diameter
    < 50 103 (46.4%) 250 (69.3%)
    ≥ 50 120 (53.6%) 111 (30.7%) <0.001
Microscopic type
    Differentiated 81 (36.3%) 205 (56.8%)
    Undifferentiated 142 (63.7%) 156 (43.2%) <0.001
Depth of tumor invasion
    T1-2 73 (32.7%) 264 (73.1%)
    T3-4 150 (67.3%) 97 (26.9%) <0.001
Lymph node metastasis
    N0 83 (37.2%) 246 (68.1%)
    N1-3 140 (62.8%) 115 (31.9%) <0.001
Lymphatic invasion
    Absent 56 (25.1%) 204 (56.5%)
    Present 167 (74.9%) 157 (43.5%) <0.001
Venous invasion
    Absent 176 (84.2%) 305 (79.1%)
    Present 47 (15.8%) 56 (20.9%) 0.109
Ascites cytology
    Negative 174 (78.0%) 346 (95.8%)
    Positive 49 (22.0%) 15 (4.2%) <0.001
Peritoneal metastasis
    Absent 200 (89.7%) 349 (96.7%)
    Present 23 (10.3%) 12 (3.3%) 0.001
Hepatic metastasis
    Negative 216 (96.9%) 354 (98.1%)
    Positive 7 (3.1%) 7 (1.9%) 0.409
pStage
    I, II 99 (44.4%) 285 (78.9%)
    III, IV 124 (55.6%) 76 (21.1%) <0.001