Table 1. Correlation between the expression of THBS4 in tumor stromal cells and clinicopathologic features in 584 patients with gastric carcinoma.
THBS4 | |||
---|---|---|---|
High (n = 223, 38.2%) |
Low (n = 361, 61.8%) |
p value | |
Age (year-old) | |||
< 65 | 105 (47.1%) | 151 (41.8%) | |
≥ 65 | 118 (52.9%) | 210 (58.2%) | 0.247 |
Gender | |||
Female | 97 (43.5%) | 162 (44.9%) | |
Male | 126 (56.5%) | 199 (55.1%) | 0.810 |
αSMA expression | |||
High | 139 (62.3%) | 136 (37.7%) | |
Low | 84 (37.7%) | 225 (62.3%) | <0.001 |
Macroscopic type | |||
type 4 | 52 (23.3%) | 9 (2.5%) | |
Other types | 171 (76.7%) | 352 (97.5%) | <0.001 |
Tumor diameter | |||
< 50 | 103 (46.4%) | 250 (69.3%) | |
≥ 50 | 120 (53.6%) | 111 (30.7%) | <0.001 |
Microscopic type | |||
Differentiated | 81 (36.3%) | 205 (56.8%) | |
Undifferentiated | 142 (63.7%) | 156 (43.2%) | <0.001 |
Depth of tumor invasion | |||
T1-2 | 73 (32.7%) | 264 (73.1%) | |
T3-4 | 150 (67.3%) | 97 (26.9%) | <0.001 |
Lymph node metastasis | |||
N0 | 83 (37.2%) | 246 (68.1%) | |
N1-3 | 140 (62.8%) | 115 (31.9%) | <0.001 |
Lymphatic invasion | |||
Absent | 56 (25.1%) | 204 (56.5%) | |
Present | 167 (74.9%) | 157 (43.5%) | <0.001 |
Venous invasion | |||
Absent | 176 (84.2%) | 305 (79.1%) | |
Present | 47 (15.8%) | 56 (20.9%) | 0.109 |
Ascites cytology | |||
Negative | 174 (78.0%) | 346 (95.8%) | |
Positive | 49 (22.0%) | 15 (4.2%) | <0.001 |
Peritoneal metastasis | |||
Absent | 200 (89.7%) | 349 (96.7%) | |
Present | 23 (10.3%) | 12 (3.3%) | 0.001 |
Hepatic metastasis | |||
Negative | 216 (96.9%) | 354 (98.1%) | |
Positive | 7 (3.1%) | 7 (1.9%) | 0.409 |
pStage | |||
I, II | 99 (44.4%) | 285 (78.9%) | |
III, IV | 124 (55.6%) | 76 (21.1%) | <0.001 |