Table 1.

Eosinophilic Chronic Obstructive Pulmonary Disease–associated Genes and Pathways in the COPDGene Study

Analysis	Comparison	Number of Differentially Expressed Genes	Top Differentially Expressed Genes	Pathway Analysis
Differential expression	Eosinophilic vs. noneosinophilic COPD	505	SMPD3	GO:0050865 regulation of cell activation
			SLC29A1	GO:0001655 urogenital system development
			PIK3R6	GO:0022407 regulation of cell–cell adhesion
			PRSS33	GO:0044262 cellular carbohydrate metabolic process
			CLC
	Eosinophilic COPD vs. eosinophilic controls	0	—	—
	Eosinophilic COPD exacerbators vs. nonexacerbators	3	NUDT5	—
			ANKRD40
			BCCIP
Eosinophil-associated genes	Eosinophilic COPD (n = 49)	378	ACSM3	GO:0030099 myeloid cell differentiation
			IL5RA	GO:0046434 organophosphate catabolic process
			ADORA3	GO:1903706 regulation of hemopoiesis
			TEC
			CYSLTR2
	Noneosinophilic COPD (n = 182)	114	SIGELC8	NA
			IL5RA
			ADGRE4P
			OLIG2
			SLC29A1
	Eosinophilic control subjects (n = 33)	0		—

Definition of abbreviations: ACSM3 = acyl-CoA synthetase medium chain family member 3; ADGRE4P = adhesion G protein-coupled receptor E4, Pseudogene; ADORA3 = adenosine A3 receptor; ANKRD40 = ankyrin repeat domain 40; BCCIP = BRCA2 and CDKN1A interacting protein; CLC = Charcot-Leyden crystal galectin; COPD = chronic obstructive pulmonary disease; COPDGene = genetic epidemiology of COPD; CYSLTR2 = cysteinyl leukotriene receptor 2; GO = gene ontology; IL5RA = IL-5 receptor subunit α; OLIG2 = oligodendrocyte transcription factor 2; NA = not applicable; NUDT5 = nudix hydrolase 5; PIK3R6 = phosphoinositide-3-kinase regulatory subunit 6; PRSS33 = serine protease 33; SIGELC8 = sialic acid-recognizing Ig-like lectin 8; SLC29A1 = solute carrier family 29 member 1 (Augustine Blood Group); SMPD3 = sphingomyelin phosphodiesterase 3; TEC = Tec Protein tyrosine kinase.