Overall survival (OS) of AML (non–acute promyelocytic leukemia [APL]) by time period, age at diagnosis, and sex. Age <50 years (n = 825, P = .67) (A); age 50 to 59 years (n = 805, P = .003) (B); age 60 to 75 years (n = 2708, P = .00002) (C); age >75 years (n = 2657, P = .50) (D); women age 50 to 75 years (n = 1564, P = .69) (E); and men age 50 to 75 years (n = 1949, P < .00001) (F). Lines represent the 4 time periods, distinguished by their length of follow-up.