Fig. 5.

CGSA showing axolotl wound healing signatures in AGMs. a Heatmap of Wound Healing Network genes in axolotl wound repair and acute SIV infection, ordered by day 1 of aquatic axolotl wound repair. The biological functions that correlate with D1 axolotl wound repair, and their associated genes are shown on the right. b A protein interaction network between proteins encoded by genes in the Wound Healing Network. Red and blue nodes indicate up and downregulation in aquatic (left) and terrestrial (right) axolotl at day 1. c Immunohistochemistry staining of fibronectin (FN) in rectal mucosa at baseline, D1 and D3 post SIV inoculation. Right panels show quantification by pixel density, middle and left panels show fibronectin protein expression in lamina propria. Representative images are shown below. The scale bar included in each image represents a length of 50 μm