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. 2019 Nov 8;9:16398. doi: 10.1038/s41598-019-52916-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival analysis of prioritized lipid species. (A) Lipid species with adjusted p-values < 0.1 in analyses of association with eGFR or logUACR slope entered the Cox proportional hazard model for progression to the combined renal endpoint consisting of ≥30% decrease in eGFR, ESRD and all-cause mortality with time to first event. (B) Significant lipids from the crude model of the combined endpoint are tested for each separate endpoint with time to each type of event. HRs are presented per 1 SD increase of the log2 lipid. Adjusted HRs (right) controlled for age, sex, HbA_1c, systolic blood pressure, smoking, BMI, statin treatment, p-triglycerides, total p-cholesterol, eGFR and logUAER. PC phosphatidylcholine, TG triacylglycerol, SM sphingomyelin.