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. 2019 Nov 8;9:16372. doi: 10.1038/s41598-019-52785-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROC curves for using ADC (blue line) or DCE (green line) as predictors of early response in 62 patients with invasive breast cancer. The best percent ADC increase cutoff value for differentiating responders from non-responders after the first cycle of NCT was 25%, and the area under the ROC curve was 0.840 (95% confidence interval: 0.728, 0.953). The latter had a greater area under the curve compared with tumor size, thereby indicating that DW-MRI is a more effective method for predicting early NCT response than evaluating tumor size with DCE-MRI.