Table 1.
Histological characteristics and ADC values evaluated prior to NCT.
| Histological Results | ADC MR1 average (×10−3 mm2/s) | ||||
|---|---|---|---|---|---|
| Overall mean ADC (95% CI) | Sig 1 | pCR (n = 24) | non-pCR (n = 38) | Sig 2 | |
| Tumor histology | P = 0.15 | ||||
| Invasive ductal carcinoma | 0.849 (0.483–1.330) | 0.854 (0.596–1.330) | 0.845 (0.483–1.280) | P = 0.601 | |
| Invasive lobular carcinoma | 0.749 (0.448–0.988) | 0.593 (0.448–0.738) | 0.811(0.699–0.988) | P = 0.190 | |
| Others | 1.073 (0.756–1.390) | — | 1.07 (0.756–1.390) | — | |
| Histologic grade (SBC) | P = 0.10 | ||||
| II | 0.884 (0.483–1.390) | 0.925 (0.751–1.170) | 0.870 (0.483–1.39) | P = 0.518 | |
| III | 0.809 (0.448–1.330) | 0.786 (0.448–1.330) | 0.831 (0.620–1.030) | P = 0.191 | |
| Estrogen receptor | P = 0.02 | ||||
| Positive | 0.789 (0.483–1.090) | 0.751 (0.596–0.103) | 0.796 (0.483–1.090) | P = 0.275 | |
| Negative | 0.897 (0.448–1.390) | 0.853 (0.448–1.330) | 0.961 (0.739–1.39) | P = 0.071 | |
| Progesterone receptor | P = 0.02 | ||||
| Positive | 0.782 (0.483–1.090) | 0.663 (0.596–0.751) | 0.796 (0.483–1.090) | P = 0.051 | |
| Negative | 0.896 (0.448–1.390) | 0.857 (0.448–1.330) | 0.961 (0.739–1.39) | P = 0.082 | |
| HER-2 | P = 0.75 | ||||
| Positive | 0.823 (0.651–1.140) | 0.831 (0.655–0.988) | 0.826 (0.651–1.140) | P = 0.733 | |
| Negative | 0.851 (0.448–1.390) | 0.862 (0.483–1.390) | 0.834 (0.448–1.330) | P = 0.451 | |
| Tumor phenotype | P = 0.12 | ||||
| Luminal B | 0.795 (0.483–1.090) | 0.755 (0.596–1.035) | 0.802 (0.483–1.090) | P = 0.359 | |
| Triple-negative | 0.917 (0.448–1.390) | 0.857 (0.448–1.330) | 1.02 (0.739–1.390) | P = 0.070 | |
| HER-2 | 0.834 (0.651–1.140) | 0.826 (0.651–1.140) | 0.847 (0.772–0.949) | P = 0.522 | |
Note: Sig1 refers to statistical significance between the categories in the left column; Sig2 refers to statistical significance between the pCR and non-pCR groups in the same line.
Statistical significance determined with Mann-Whitney test, P = 0.05.
ADC: apparent diffusion coefficient; NCT: neoadjuvant chemotherapy; MR1: MR exam prior to treatment; CI: confidence interval; pCR: complete pathological response; non-pCR: an absence of complete pathological response.