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. 2019 Nov 8;9:16298. doi: 10.1038/s41598-019-52801-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sequences of the β-PV isoforms of Gadus morhua and Scomber japonicus. (a) Sequence alignment generated using BioEdit tools and their amino acid color table. (b) Pairwise identity calculated using BioEdit tools. (c) Relevant regions for PARV19 and serum IgE binding. The PARV19 epitope (orange rectangle) was predicted to include residues 13–39³⁶. The displayed IgE binding epitopes (red rectangles) were determined using gmPV1-templated dodecapeptides²⁵. (d) Segments involved in the globular and amyloid folds of β-PV. The globular fold contains three helix-loop-helix (AB, CD and EF) EF-hands, of which only CD and EF bind cations^3,4,26,43. Regions assembling into amyloids were predicted by AmylPred2, and they are depicted by arrows. Regions known to form amyloids in gmPV1 are depicted with pink arrows^25,30.