Table 2.
Overexpression of CCNE1 and CCNE2 in breast cancers
| Basal-like | HER2 | Luminal A | Luminal B | Normal-like | |
|---|---|---|---|---|---|
| CCNE1 OE | |||||
| Sample size, n | 91 | 116 | 130 | 172 | 6 |
| Yes | 88 | 94 | 52 | 53 | 1 |
| No | 3 | 22 | 78 | 119 | 5 |
| % OE | 96.7 | 81.0 | 40.0 | 30.8 | 16.7 |
| CCNE2 OE | |||||
| Sample size, n | 91 | 116 | 130 | 172 | 6 |
| Yes | 81 | 112 | 109 | 110 | 1 |
| No | 10 | 4 | 21 | 62 | 5 |
| % OE | 89.0 | 96.6 | 83.8 | 64.0 | 16.7 |
TCGA RNAseq Data set were downloaded from Broad Institute Firehose website (https://gdac.broadinstitute.org; BRCA cohort). An arbitrary cutoff threshold at two SD above median normal expression of that gene (log2 RSEM of 5.736 and 6.925 for CCNE1 and CCNE2, respectively). Tumors with expression level above a cutoff were considered as having overexpression (OE)