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. 2019 Nov 8;9:16313. doi: 10.1038/s41598-019-52814-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of ALDH3A1 is associated with poor survival of patients with gastric cancer. Knockdown of ALDH3A1 inhibits proliferation of gastric cancer cells. (a) Kaplan–Meier survival curve. GC patients positive for ALDH3A1 (n = 673) had a worse prognosis than those that were negative for ALDH3A1 (n = 459) (p = 0.0146, log-rank test). (b) Representative images of immunohistochemical staining of ALDH3A1. Scale bar Re20 µm. (c) Western blot showing higher expression of ALDH3A1 by gastric cancer cell lines compared with other ALDH isotypes. (d) Small interfering (si)RNA-mediated knockdown of ALDH3A1, as assessed by Western blotting. (e) Knockdown of ALDH3A1 suppressed proliferation of gastric cancer cells in an SRB assay. Data are expressed as the mean and standard deviation of three independent experiments. *p <0.05, **p <0.01, ***p <0.001.