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. 2019 Nov 8;9:16322. doi: 10.1038/s41598-019-52892-1

Figure 1.

Figure 1

The optimal dose of topical Cal in mice with IMQ-induced psoriasis-like dermatitis. Mice received topical application of IMQ cream on the ear for 6 consecutive days, and were treated with 0.02, 0.06, 0.2, 0.6, and 2 nmol of Cal 1 h before IMQ application. Normal mice were used as a negative control. (A) Ear thickness was measured every day. (B) Body weight was measured every three days during the experiment. The values and vertical bar represent the mean ± SE of 4 mice. *p < 0.05, **p < 0.01, ***p < 0.001 vs. vehicle group by Dunnett test among the vehicle, Cal, BDP, and Cal/BDP groups.