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. 2019 Nov 8;9:16380. doi: 10.1038/s41598-019-52532-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Common homologs E-values distribution of BLOSUM and EDSSMat series of matrices. For representative purpose comparison of log10(E-values) distributions of common homologs of BLOSUM62 and EDSSMat62 on three different test datasets: (a) Highly Disordered (HD); (b) Moderately Disordered (MD); and (c) Less Disordered (LD) is shown here. EDSSMat62 matrix achieved lower E-values on dataset comprised of highly disordered proteins i.e. HD test dataset, whereas BLOSUM62 attained lower E-values on dataset enriched with ordered regions. Difference in E-values distributions are statistically significant (wilcoxon test, p-value is < 2.2e-16).